Efforts to identify genes other than HLA-B27 in AS have been driven by the strength of the evidence from genetic epidemiology studies indicating that HLA-B27, although a major gene in AS, is clearly not the only significant gene operating. This is the case for both genetic determinants of disease-susceptibility and phenotypic characteristics such as disease severity and associated disease features. In this chapter the genetic epidemiology of AS and the gene-mapping studies performed to date will be reviewed and the future direction of research in this field discussed. © 2009 Landes Bioscience and Springer Science+Business Media.
CITATION STYLE
Brown, M. A. (2009). Genomewide screens in ankylosing spondylitis. Advances in Experimental Medicine and Biology, 649, 148–158. https://doi.org/10.1007/978-1-4419-0298-6_11
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