Assessment of Urea and Creatinine in Vaginal Washing Fluid as a Method for Diagnosis of Premature Rupture of Membranes

Abstract

Background: Premature rupture of membranes (PROM) refers to rupture of fetal membranes prior the onset of labor. If it occurs before 37 weeks of pregnancy, it is known as preterm premature rupture of membrane (PPROM). Prolonged duration from PROM till delivery is associated with increased maternal and neonatal morbidities, in term and preterm pregnancies. This includes chorioamnionitis, fetal and neonatal sepsis, placental abruption, prematurity, umbilical cord pro-lapse, and increased rate of cesarean delivery.