Oxygen-Dependent and Oxygen-Independent Effects of Perftoran

Abstract

A brief review of the main properties of the low-concentrated emulsion Perftoran which contains perfluorodecalin and perfluoromethylcyclohexylpiperidine rapidly and slowly eliminated from the organism respectively. Perftoran carries an expected small volume of oxygen, but improves the oxygen regime in tissues and organisms due to kinetic acceleration of the oxygen flow and facilitates functions of the remaining erythrocytes. Activation of Adenosine triphosphate (ATP) synthesis in rat liver mitochondria after massive blood replacement and an improvement of the energy state and the survival of kidney grafts isolated during a severe hemorrhagic shock served as good indexes of the sufficient oxygen delivery by Perftoran. It has relatively low reactogenicity of Perftoran due to a small average particle size of emulsion of about 0.07 mum. The allowed threshold in particles size is smaller than 0.14 mum for Perftoran. The main oxygen-independent properties of Perftoran are the following: a decrease in rigidity of heart muscle during cardioplegia due to a reversible inhibition of Ca-current and a decrease in its sensitivity to epinephrine; immunosuppressive effect is connected with the inhibition of hyperactivated macrophages and primed neutrophils; de novo synthesis of the phenobarbital isoforms of P450 in liver is induced by perfluorodecalin.