Venous thromboembolism and atherosclerosis: Is there a link?

77Citations
Citations of this article
41Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

After the initial demonstration provided 4 years ago by a case-control study in the New England Journal of Medicine , numerous investigations have addressed the association between venous and arterial thrombotic disorders. According to the results of recent studies, the two conditions are likely to share common risk factors, including age, obesity, cigarette smoking, diabetes mellitus, arterial hypertension, hyperlipemia and metabolic syndrome. The nature of this association is unclear. On the one hand, atherosclerosis has the potential to promote the development of thrombotic disorders in the venous system. On the other hand, the two clinical conditions can be simultaneously triggered by biological stimuli responsible for activating coagulation and inflammatory pathways in both the arterial and the venous system. Based on the results of two population-based studies carried out in the USA, atherosclerosis is unlikely to constitute a risk factor for venous thromboembolic (VTE) disorders. Several recent studies have consistently shown that subjects with VTE of unknown origin are at a higher risk of subsequent arterial cardiovascular events than subjects with secondary VTE and matched control individuals. In conclusion, the separate nature of arterial and venous disorders has been challenged. Future studies are needed to clarify the nature of this association, to assess its extent, and to evaluate its implications for clinical practice. © 2007 International Society on Thrombosis and Haemostasis.

References Powered by Scopus

The long-term clinical course of acute deep venous thrombosis

2017Citations
N/AReaders
Get full text

HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY

1968Citations
N/AReaders
Get full text

Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris

1619Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Risk of recurrence after venous thromboembolism in men and women: Patient level meta-analysis

240Citations
N/AReaders
Get full text

Association of traditional cardiovascular risk factors with venous thromboembolism

118Citations
N/AReaders
Get full text

Prevalence and risk factors of retinal vein occlusion: The Gutenberg Health Study

104Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Prandoni, P. (2007). Venous thromboembolism and atherosclerosis: Is there a link? Journal of Thrombosis and Haemostasis. Blackwell Publishing Ltd. https://doi.org/10.1111/j.1538-7836.2007.02467.x

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 19

68%

Researcher 5

18%

Professor / Associate Prof. 3

11%

Lecturer / Post doc 1

4%

Readers' Discipline

Tooltip

Medicine and Dentistry 20

80%

Nursing and Health Professions 3

12%

Materials Science 1

4%

Pharmacology, Toxicology and Pharmaceut... 1

4%

Save time finding and organizing research with Mendeley

Sign up for free