Presencia de los alelos DRD4/7R y DAT1/10R en miembros de familias chilenas con síndrome de déficit atencional con hiperactividad

Abstract

Background: Genes for dopamine receptor DRD4 and dopamine transporter DAT1 have been implicated in attention deficit with hyperactivity disorder (ADHD). However, the findings are not conclusive. More studies in populations with different genetic brackgrounds may contribute to solve the discrepancies observed. Aim: To test the hypothesis that affected members of Chilean families exhibit higher frequencies of the DRD4/7R and DAT1/10R alleles then their healthy sibs. Material and Methods: The parents of 51 children belonging to families of the Metropolitan Region of Chile, were approached to obtain clinical histories and blood samples, after the signature of a written informed consent. ADHD was diagnosed according to DSM-IV criteria, and intellectual coefficient was tested using the WISC-R test. Genomic DNA was extracted from lymphocytes and amplified by PCR. Results: The 7R allele was identified in 13 out of 26 subjects diagnosed as ADHD and in 6 of 25 healthy sibs (p <0.05). Parents with a history of ADHD, were compared with their healthy counterparts, exhibiting an identical tendency, that did not reach statistical significance. No significant differences in the frequencies of DAT1/10R alleles, were observed between cases and controls or their parents. Conclusions: Our results showed that ADHD in Chilean families is associated with the presence of DRD4/7R allele.