Gypsetin, a new inhibitor of ACYL-CoA: Cholesterol acyltransferase produced by nannizzia gypsea var. Incurvata IFO 9228. II. Structure determination

Abstract

The elucidation of the structure of gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase, is described in this paper. By spectroscopic and X-ray crystallographic analyses, the structure of gypsetin has been determined to be 8a, 16a-dihydroxy-5a, 13a-bis[1, 1-dimethylallyl][1]benzazolidine[3‴, 2‴:4″, 5″]azolidino[1″, 2″:4′, 5′][1, 4]perhydrodiazin[1′,2′:1,5]azolidino[2,3-b] [1] benzazolidine-7, 15-dione. © 1994, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.