Abstract
High-performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS) provided a rapid and specific means for profiling the iodine-containing metabolites produced by the earthworm Eisenia veneta following exposure to 2-fluoro-4-iodoaniline. Profiles were obtained, using gradient reversed-phase HPLC, from extracts of whole earthworms and from coleomic fluid with as little as 25 ng/peak of iodine detected. The use of ICPMS in this way provides a convenient means of determining the metabolic fate of iodinated compounds without the need for radiolabelled compounds. Copyright © 2003 John Wiley & Sons, Ltd.
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Duckett, C. J., Wilson, I. D., Walker, H., Abou-Shakra, F., Lindon, J. C., & Nicholson, J. K. (2003). High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4-iodoaniline. Rapid Communications in Mass Spectrometry, 17(16), 1855–1858. https://doi.org/10.1002/rcm.1125
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