Childhood trauma: a risk for major depression in patients with psoriasis

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Abstract

INTRODUCTION: A history of childhood trauma is an important determinant for understanding the development of psychiatric and physical disorders. The chronic inflammatory disease, psoriasis, has been reported to be affected by childhood psychological stressors. Early life stress is also a well-known contributor to major depression. The current study aims to clarify a possible association between levels and types of childhood trauma with psoriasis severity and major depression. METHOD: Sixty-four patients diagnosed with mild-to-severe psoriasis (male = 27, mean age = 52.51 ± 14.72 years and female = 37, mean age = 42.76 ± 14.45 years, age range = 21–77) were admitted to our study between April 2014 and September 2014. For the diagnosis of psoriasis, the single most recently developed lesion was examined dermoscopically and histopathologically. We evaluated the history of childhood trauma with the Childhood Trauma Questionnaire and diagnosis of major depression with the Mini International Neuropsychiatric Interview (MINI 5.0.0 current). The participants were scanned for their severity of psoriasis with Psoriasis Area and Severity Index 75 (PASI 75). Initially, the data were checked for normality using Kolmogorov–Smirnov/Shapiro–Wilk’s tests, histograms, and probability plots. Because normality of the data could not be assumed, we evaluated childhood trauma subscales and psoriasis by running Kendell’s tau-b correlation coefficients for bivariate comparisons. Mann–Whitney U test was conducted to assess the differences in childhood trauma severity of each subscale between two groups of depressed and non-depressed patients with psoriasis. Ultimately, we ran chi-square analysis to evaluate the association between gender and depression. RESULTS: Emotional (0.325), physical (0.614), sexual (0.963) abuse, and emotional (0.331) neglect were positively correlated with higher severity of psoriasis (p

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CITATION STYLE

APA

Erfanian, M. (2018). Childhood trauma: a risk for major depression in patients with psoriasis. Psychiatry and Clinical Psychopharmacology, 28(4), 378–385. https://doi.org/10.1080/24750573.2018.1452521

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