Three Down and One To Go: Modeling Medulloblastoma Subgroups

Abstract

In this issue of Cancer Cell, Pei et al. and Kawauchi et al. describe murine models of an aggressive medulloblastoma subtype driven by Myc. These tumors have a cellular origin, microscopic appearance, and molecular profile distinct from those of three other major subgroups. Thus, the models fill a significant clinical need. © 2012 Elsevier Inc.