Research progress of aldehyde ketone reductase for asymmetric catalysis of chiral compounds

Abstract

Aldehyde ketone reductase (AKR) belongs to the redox enzyme superfamily. The aldo-keto reductase (AKR) protein superfamily contains over 190 members that fall into 16 families. Its biological catalysis in the preparation of chiral compounds has significant advantages. Therefore, application of aldehyde ketone reductase gains more benefit as industrial catalysts. Recently, a variety of microbial aldehyde ketone reductase has been used in the synthesizing the high value of chiral compounds. Here we reviewed structure and functional modification of aldehyde ketone reductase protein, gene mining of novel AKR enzyme for industrial catalysts and co-enzyme regeneration using the genome database.