Ten-Year Follow-up of Japanese Overweight Subjects with Impaired Glucose Tolerance: Identification of a Diabetes-Prone Subpopulation

Abstract

Ninety-four overweight subjects with normal glucose tolerance (NGT) or impaired glucose tolerance (IGT) were followed for 10 years. No one from the NGT group developed diabetes, however 32% of the IGT subjects did develop diabetes. Initial data of the IGT subjects who developed diabetes were significantly different from those who did not develop diabetes. Fasting, peak and/or ∑plasma glucose (PG), IRI and CPR at 180 minutes and CPR/IRI at 0 and 180 minutes were increased, and the peak time of PG was delayed; also the prevalence of a positive family history was higher, and the body weight heavier. Seventy-nine percent of IGT subjects with the initial ∑PG of≥40 mM or a positive family history developed diabetes whereas only 3% of those with ∑PG of <40 mM and a negative family history developed diabetes. Therefore, it might be considered that among the overweight adults with IGT, those with SPG of ≥40 mM or a positive family history are diabetes prone and those with ∑PG of <40 mM and a negative family history are diabetes resistant. © 1992, The Japanese Society of Internal Medicine. All rights reserved.