The angular distribution of directional changes of guided 3T3 cells

Abstract

This paper reports that the angular distribution of directional change of 3T3 cells which followed guiding lines on a substrate and left the guidance at various angles shows a peculiar preference of angles between 30° and 60°. Regarding the phenomenon of cellular guidance itself, 3T3 cells faced with a choice between guiding lines toward different directions seem to explore various options before following one. This observation suggests that the outcome of a probing action and not substrate properties alone can explain the guidance behavior of 3T3 cells.