Clusters of multidrug-resistant Mycobacterium tuberculosis cases, Europe

71Citations
Citations of this article
74Readers
Mendeley users who have this article in their library.

Abstract

Molecular surveillance of multidrug-resistant tuberculosis (MDR TB) was implemented in Europe as case reporting in 2005. For all new MDR TB cases detected from January 2003 through June 2007, countries reported case-based epidemiologic data and DNA fingerprint patterns of MDR TB strains when available. International clusters were detected and analyzed. From 2003 through mid-2007 in Europe, 2,494 cases of MDR TB were reported from 24 European countries. Epidemiologic and molecular data were linked for 593 (39%) cases, and 672 insertion sequence 6110 DNA fingerprint patterns were reported from 19 countries. Of these patterns, 288 (43%) belonged to 18 European clusters; 7 clusters (242/288 cases, 84%) were characterized by strains of the Beijing genotype family, including the largest cluster (175/288 cases, 61%). Both clustering and the Beijing genotype were associated with strains originating in eastern European countries. Molecular cluster detection contributes to identification of transmission profile, risk factors, and control measures.

References Powered by Scopus

Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology

2574Citations
N/AReaders
Get full text

Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: Recommendations for a standardized methodology

2218Citations
N/AReaders
Get full text

Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa

1430Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

870Citations
N/AReaders
Get full text

Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains

327Citations
N/AReaders
Get full text

Transmission of extensively drug-resistant tuberculosis in South Africa

225Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Devaux, I., Kremer, K., Heersma, H., & Van Soolingen, D. (2009). Clusters of multidrug-resistant Mycobacterium tuberculosis cases, Europe. Emerging Infectious Diseases, 15(7), 1052–1060. https://doi.org/10.3201/eid1507.080994

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 29

55%

Researcher 19

36%

Professor / Associate Prof. 4

8%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Medicine and Dentistry 28

53%

Agricultural and Biological Sciences 17

32%

Biochemistry, Genetics and Molecular Bi... 4

8%

Immunology and Microbiology 4

8%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free