Abstract
Pancreatic cancer (PC) is one of the most fatal malignant tumors across the world. STAT-3 is involved in PC growth and metastasis. STAT-3 is a transcription factor that regulates many oncogenic transduction pathways. In the current chapter, we discuss the importance of STAT-3 in hypoxia and hypoxia-inducible genes. Further, we also explore the inhibition of STAT-3 by phytochemicals such as curcumin and genistein.
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Rajitha, B., & Nagaraju, G. P. (2018). Curcumin and genistein role in regulation of STAT-3 in pancreatic cancer. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 423–431). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_32
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