Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

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Abstract

Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the inflammatory response through its action upon a diverse population of cells. Recently this immunomodulator has been detected at sites of traumatized brain. As reported here, recombinant forms of IL-1 injected into the cerebral cortex of adult rats elicited not only astrogliosis but also new blood vessel growth. These responses are typical of brain injury and suggest that IL-1-secreting inflammatory cells may mediate wound healing in the CNS.

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Giulian, D., Woodward, J., Young, D. G., Krebs, J. F., & Lachman, L. B. (1988). Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. Journal of Neuroscience, 8(7), 2485–2490. https://doi.org/10.1523/jneurosci.08-07-02485.1988

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