Irisin in adolescent type 1 diabetic patients and its relation to diabetes control and atherosclerosis

Abstract

AIM: The objective of the study was to determine the role of irisin in adolescent type 1 diabetic patients. PATIENTS AND METHODS: Sixty-five type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum irisin, glycosylated hemoglobin (HbA1c), lipid profile, oxidized low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio, carotid intimal-medial thickness (cIMT), and aortic intimal medial thickness (aIMT) were assessed for all participants in the study. RESULTS: HbA1c, albumin/creatinine ratio, lipid profile, OxLDL, irisin, cIMT, and aIMT were significantly higher in diabetic patients. Irisin had a positive correlation with age of diabetic patients, onset of diabetes, mid-arm circumference, waist/height ratio, body mass index, HbA1c, and cIMT. CONCLUSION: Irisin is a marker for detection of diabetes control and early detection of subclinical atherosclerosis. Irisin had a relation with obesity.