There are several classes of illegal substances with different psychotropic effects. It is possible to select a biological matrix and a suitable analytical strategy depending on the aim of the analysis and/or on the availability of the sample or on which kind of information is needed. Liquid chromatography-mass spectrometry (LC-MS or LC-MS/MS) has provided a helpful tool in this field especially for hydrophilic, thermolabile, and nonvolatile analytes, which analysis is sometimes critical by gas chromatography-mass spectrometry (GC-MS). Specific guidelines or procedures have been adopted in order to assist the chemist and to direct him/her towards the practical applications, for which a new analytical method is being created, including measures of verification and external assessment.
CITATION STYLE
Sergi, M., & Napoletano, S. (2012). Analysis of illicit drugs in human biological samples by LC-MSn. In LC-MS in Drug Bioanalysis (Vol. 9781461438281, pp. 349–398). Springer US. https://doi.org/10.1007/978-1-4614-3828-1_12
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