The RZZ complex and the spindle assembly checkpoint

Abstract

The conserved protein Rod is found in various organisms. It is localized on the kinetochores or spindle microtubules during cell division. Rod is required for proper chromosome segregation during both mitosis and meiosis. The effects of rod mutations are similar for both equational and reductional divisions, giving rise to anaphases with lagging chromosomes and/or unequal numbers of chromosomes at the two poles. Recent studies have shown that Rod is a significant component of the mitotic checkpoint. It can form the RZZ complex with Zw10 and Zwilch, which plays an important role in maintaining a functional spindle assembly checkpoint. © 2009 by Japan Society for Cell Biology.