Biochemical Approach of Acid-Base Disturbances

Abstract

Introduction: The current paradigms in arterial blood gas analysis are based on mathemati-cal or physicochemical models that require complex algorithms for interpretation. This leads to avoidance or dislike from health care professionals. Objectives: To formulate a new approach to the analysis and classification of acid base distur-bances. Methodology: We conducted a systematic review of the related literature and a paradigm shift for data interpretation. Results: Acid-base disorders can be grouped and managed according to the underlying biochemical processes. Discussion and Conclusions: This proposal represents a new classification, which groups acid base disorders according to the underlying causal biochemical process. Disorders with an eleva-ted anion gap relate to alterations in cellular respiration (energy/ATP production)-All disturban-ces with normal anion gap relate to transmembrane ion exchange.