Biomarkers in orthodontics: A review

Abstract

The examination of Gingival crevicular fluid (GCF) may be considered an acceptable way to depict the biochemical changes occurring during orthodontic tooth movement. Correlating the changes taking place in GCF with different types of orthodontic forces, the patient can be managed based on individual patients’ tissue response. Thus, this can be an effective way of improving treatment efficiency and results. There is little evidence regarding which GCF biomarkers are associated with the growing phase. Most of the earlier reports provide information about correlation of GCF biomarkers with inflammation, bone remodeling and tissue damage and other processes associated with orthodontic tooth movement. This method is not being clinically used to its full diagnostic potential and requires further studies to provide additional data.