In the 19th century Gregor Mendel defined the laws of genetic inheritance by crossing different types of peas. 1 From these results arose his principle of equivalence: the gene will have the same behaviour whether it is inherited from the mother or the father. Today, several key exceptions to this principle are known, for example sex-linked traits and genes in the mitochondrial genome, whose inheritance patterns are referred to as 'non mendelian'. A third, important exception in mammals is that of genomic imprinting, where transcripts are expressed in a monoallelic fashion from only the maternal or the paternal chromosome. In this chapter, we discuss how parent-of-origin effects and genomic imprinting may play a role in autoimmunity and speculate how imprinted miRNAs may influence the expression of many target autoimmune associated genes. © 2011 Landes Bioscience and Springer Science+Business Media.
CITATION STYLE
Camprubí, C., & Monk, D. (2011). Does genomic imprinting play a role in autoimmunity? Advances in Experimental Medicine and Biology, 711, 103–116. https://doi.org/10.1007/978-1-4419-8216-2_8
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