The spatial distribution of the transverse nuclear spin magnetization, appearing in a single compartment with impermeable boundaries in a Stejskal-Tanner gradient pulse MR experiment, is analyzed in detail. At short diffusion times the presence of diffusion-restrictive barriers (membranes) reduces effective diffusivity near the membranes and leads to an inhomogeneous spin magnetization distribution (the edge-enhancement effect). In this case, the signal reveals a quasi-two-compartment behavior and can be empirically modeled remarkably well by a biexponential function. The current results provide a framework for interpreting experimental MR data on various phenoma, including water diffusion in giant axons, metabolite diffusion in the brain, and hyperpolarized gas diffusion in lung airways. © 2003 Wiley-Liss, Inc.
CITATION STYLE
Sukstanskii, A. L., Ackerman, J. J. H., & Yablonskiy, D. A. (2003). Effects of barrier-induced nuclear spin magnetization inhomogeneities on diffusion-attenuated MR signal. Magnetic Resonance in Medicine, 50(4), 735–742. https://doi.org/10.1002/mrm.10586
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