Pharmacokinetic of simvastatin study in Malaysian subjects

Abstract

-The pharmacokinetic of simvastatin 40 mg tablet was assessed in 9 healthy Malaysian male subjects after a single oral dose in Pinang Hospital, Malaysian. Blood samples were collected at specified time intervals, plasma separated and analyzed for simvastatin using validated LC-MS-MS method at unversiti sains Malaysia. The pharmacokinetic parameters AUC 0-24 C max , T max , t 1/2 , K e , Cl and V d were determined from plasma concentration-time profile for simvastatin. The results of this current method were consistent with other methods previously reported.