Abstract
IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases. Copyright © 2012 S. Karger AG, Basel.
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Tojo, G. I., Fujimura, T., Kambayashi, Y., & Aiba, S. (2012). Systemic lupus erythematosus accompanied by psoriasis induces IL-27-producing cells in both affected areas of the skin. Case Reports in Dermatology, 4(2), 181–185. https://doi.org/10.1159/000342803
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