N-Succinyl-chitosan has favourable properties as a drug carrier, such as biocompatibility, low toxicity and long-term retention in the body. It is a good candidate for cancer chemotherapy as a polymeric drug carrier. This study describes the preparation and characterization of 5-fluorouracil-loaded N-succinyl-chitosan nanoparticles (5-FU-Suc-Chi/NP) by an emulsification solvent diffusion method. The influence of the initial 5-FU concentration on the nanoparticle characteristics and release behaviour in phosphate-buffered saline solution (PBS) was evaluated. The Suc-Chi nanoparticles had a particle diameter (Z-average) in the range 202∼273 nm and a negative zeta-potential (approx. −27 to −18 mV). The formulation with an initial 5-FU concentration of 1000 μg mL−1 provided the highest loading capacity (19%) and the highest extent of release (61% at 24 h). The 5-FU-Suc-Chi/NP showed good anti-tumour activity against Sarcoma 180 solid tumour and mild toxicity. According to the data obtained, this Suc-Chi-based nanotechnology opens new and interesting perspectives for cancer chemotherapy.
CITATION STYLE
Yan, C., Chen, D., Gu, J., & Qin, J. (2010). Nanoparticles of 5-fluorouracil (5-FU) loaded N -succinyl-chitosan (Suc-Chi) for cancer chemotherapy: preparation, characterization — in-vitro drug release and anti-tumour activity. Journal of Pharmacy and Pharmacology, 58(9), 1177–1181. https://doi.org/10.1211/jpp.58.9.0003
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