Finite Element Modelling of In-Stent Restenosis

Abstract

From the perspective of coronary heart disease, the development of stents has come significantly far in reducing the associated mortality rate, drug-eluting stents being the epitome of innovative and effective solutions.Within thiswork, the intricate process of in-stent restenosis is modelled considering one of the significant growth factors and its effect on constituents of the arterial wall. A multiphysical modelling approach is adopted in this regard. Experimental investigations from the literature have been used to hypothesize the governing equations and the corresponding parameters. A staggered solution strategy is utilised to capture the transport phenomena as well as the growth and remodeling that follows stent implantation. The model herein developed serves as a tool to predict in-stent restenosis depending on the endothelial injury sustained and the protuberance of stents into the lumen of the arteries.