A novel approach to protein structure prediction using PCA or LDA based extreme learning machines

Abstract

In the area of bio-informatics, large amount of data is harvested with functional and genetic features of proteins. The structure of protein plays an important role in its biological and genetic functions. In this study, we propose a protein structure prediction scheme based novel learning algorithms - the extreme learning machine and the Support Vector Machine using multiple kernel learning, The experimental validation of the proposed approach on a publicly available protein data set shows a significant improvement in performance of the proposed approach in terms of accuracy of classification of protein folds using multiple kernels where multiple heterogeneous feature space data are available. The proposed method provides the higher recognition ratio as compared to other methods reported in previous studies. © 2012 Springer-Verlag.