ANTIMICROBIAL POTENTIAL OF HALOALKALIPHILIC BACILLUS THERMOTOLERANS FROM ALKALINE ENVIRONMENT

Abstract

Day-by-day, because of the irregular and indiscriminate use of the antimicrobial drugs in treatment of infectious diseases leading to increase in the rapid spread of multidrug-resistant bacteria, re-emergent infections, and newly emerging infectious diseases and have become a serious global public health threat, specifically affecting the economic development Therefore, the study was undertaken to find new antibacterial producer from extreme environment like Lonar Lake. In present study, Bacillus thermotolerans, isolated from Lonar Lake, showed the most prominent antimicrobial activity and maximum antimicrobial sensitivity index against most of the enteric pathogens. GCMS analysis recorded the presence of antimicrobial components such as Ethyl cyclopropanecarboxylate, Squalene, Decanedioic acid, bis (2-ethylhexyl) ester, 5-Cyclopropylcarbonylontaxypentadecane, Octadecanoic acid, Z-10-Tetradecen-1-ol acetate, n-Hexadecanoic acid, Pyrrolo (1,2-a) pyrazine-1,4 dione, hexahydro-3(2-methylpropyl) and 4-Heptanol, 2,6-dimethyl. Our study provides primary evidence that Bacillus thermotolerans from Lonar Lake has the capacity to provide active and high antimicrobial secondary metabolites which have potential in medical and pharmaceutical industry.