Antifungal and antioxidant pyrrole derivative from Piper pedicellatum

Abstract

In continuation of our search for efficient pest control natural products from the flora of the South Eastern Sub-Himalayan biodiversity region, we have investigated wild edible Piper pedicellatum C. DC (Piperaceae) from Arunachal Pradesh, India against five important plant pathogenic fungi through an activity guided method, and a new compound, pedicellamide, was isolated. The structure was determined on the basis of extensive spectroscopic studies and confirmed by X-ray crystallography. The compound exhibited antifungal activities against the phytopathogenic fungal organisms Rhizoctonia solani (MIC 38.4 ± 1.6 μg/mL), Fusarium oxysporum (MIC 29.7 ± 0.8 μg/mL), Aspergillus niger (MIC 48.6 ± 0.7 μg/mL), Puccinia gramini (MIC 46.8 ± 1.4 μg/mL) and Curvularia lunata (MIC 49.1 ± 0.1μg/mL). Additionally, the antioxidant potential of the compound was estimated by DPPH, ABTS and FRAP assay and found to be 2.87 ± 0.20, 2.19 ± 0.13 and 3.96 ± 0.17 VCEAC (μM/g), respectively.