TREM2 regulates innate immunity in Alzheimer's disease

62Citations
Citations of this article
129Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Recent research has shown that the triggering receptor expressed on myeloid cells 2 (TREM2) in microglia is closely related to the pathogenesis of Alzheimer's disease (AD). The mechanism of this relationship, however, remains unclear. TREM2 is part of the TREM family of receptors, which are expressed primarily in myeloid cells, including monocytes, dendritic cells, and microglia. The TREM family members are cell surface glycoproteins with an immunoglobulin-like extracellular domain, a transmembrane region and a short cytoplasmic tail region. The present article reviews the following: (1) the structure, function, and variant site analysis of the Trem2 gene; (2) the metabolism of TREM2 in peripheral blood and cerebrospinal fluid; and (3) the possible underlying mechanism by which TREM2 regulates innate immunity and participates in AD.

Cite

CITATION STYLE

APA

Li, J. T., & Zhang, Y. (2018, April 14). TREM2 regulates innate immunity in Alzheimer’s disease. Journal of Neuroinflammation. BioMed Central Ltd. https://doi.org/10.1186/s12974-018-1148-y

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free