CXCR3 blockade: a novel anti-sepsis approach?

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Abstract

Blockade of the CXC chemokine receptor 3 (CXCR3) attenuates inflammation and improves survival in a murine model of near lethal polymicrobial sepsis. However, given the multitude of cellular responses and inflammatory mediators that orchestrate sepsis syndrome, more detailed investigations will be required before a complete understanding of the mechanism(s) of CXCR3 blockade and its therapeutic potential are revealed. © 2012 BioMed Central Ltd.

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Delano, M. J., & Moldawer, L. L. (2012, November 21). CXCR3 blockade: a novel anti-sepsis approach? Critical Care. https://doi.org/10.1186/cc11818

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