RECOMBINANT DNA VACCINES.

Abstract

The field of veterinary biologics has been the primary benefactor of the limited number of genetically engineered products. Several recombinant DNA (r-DNA) vaccines used to prevent enterotoxigenic Escherichia coli disease in livestock animals are currently available world-wide (e. g. , EcoBac, and Scourguard) and a vaccine for foot and mouth disease is available in limited markets. In this paper, the author discusses the rationale behind the development of r-DNA vaccines and some of the methods used in their preparation. Discussion of viral-based vaccines is minimal, although not excluded. The details of the processes used to develop an E. coli r-DNA vaccine are used as a primary example.