Opportunity for invasive mechanical ventilation in NRDS: a retrospective cohort study in China

Abstract

Purpose: Mechanical ventilation, as a critical breathing support, plays a critical role in the treatment of neonatal respiratory distress syndrome (NRDS). We aim to describe the clinical characteristics of NRDS and give suggestions about when to start mechanical ventilation. Methods: We conducted a retrospective cohort study, enrolling 95 neonates between December 2016 and October 2021. Diagnosis of NRDS was according to the Berlin definition. Spearman’s and ROC analysis was used to determine the variables correlated with hospital stay and optimal opportunity for mechanical ventilation. Results: Ninety-five subjects with NRDS were included. Lower PaO2 and higher PaCO2 in arterial blood gas prompt longer discharge time after mechanical ventilation and total in-hospital stay (p