The results of clinical studies on the value of preemptive analgesia are far from being unanimous. There are a number of potential problems related to preemptive analgesia that could lead to controversy regarding its clinical significance. The following potential problems are analyzed: (1) terminology, (2) approach to reveal the effect of preemptive analgesia, (3) verification of the direct pharmacological effect of a treatment, (4) partial preemptive effect in control, (5) intensity of noxious stimuli, (6) difference in a drug concentration between study groups during postoperative period, and (7) outcome measures.
CITATION STYLE
Kissin, I. (2010). Preemptive analgesia: problems with assessment of clinical significance. Methods in Molecular Biology (Clifton, N.J.), 617, 475–482. https://doi.org/10.1007/978-1-60327-323-7_34
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