Early versus late administration of long-acting injectable antipsychotic agents among patients with newly diagnosed schizophrenia: An analysis of a commercial claims database

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Abstract

This study was designed to assess healthcare resource utilization (HCRU) and costs in patients with newly diagnosed schizophrenia based on timing and context of long-acting injectable antipsychotic agent (LAI) initiation. Using claims data, patients (aged 18-40 years) with first schizophrenia diagnosis January 2013-September 2019 (index date), no LAI or oral antipsychotic agent claims during 12-month preindex period, and continuous benefit enrollment from 12 months before index date to 12 months after first LAI administration were identified. Patients were grouped based on timing [early (≤1 year after index date) vs. late] and circumstances [reactive (after schizophrenia-related event) vs. proactive] of LAI initiation. Of 1290 patients with at least one LAI claim, 306 met criteria for early (n = 204; reactive, n = 107; proactive, n = 97) and late (n = 102; n = 75; n = 27) initiation. HCRU and costs were numerically lower in early versus late groups, and significantly lower for proactive initiation in both groups. Comparing worst-case (late-reactive) and best-case (early-proactive) scenarios, the average annual cost difference was $7195.13 (P = 0.0233), with major drivers being emergency department ($171.28; P < 0.05) and other outpatient ($2845.73; P < 0.00001) visits. In addition to the clinical advantages previously described in the literature, the proactive use of LAIs in early-phase schizophrenia is associated with lower healthcare costs.

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Kane, J. M., Chen, A., Lim, S., Mychaskiw, M. A., Tian, M., Wang, Y., … Rubio, J. M. (2023). Early versus late administration of long-acting injectable antipsychotic agents among patients with newly diagnosed schizophrenia: An analysis of a commercial claims database. International Clinical Psychopharmacology, 38(4), 240–248. https://doi.org/10.1097/YIC.0000000000000452

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