System-size biresonance for intracellular calcium signaling

Abstract

Using the chemical Langevin equation, the authors have addressed the effects of internal fluctuations on intracellular calcium signaling. It is found that the effect of the internal fluctuations depends on the volume of the cell. The signal-to-noise ratio (SNR; see plot) of the stochastic calcium oscillation shows two maxima, demonstrating the occurrence of system-size biresonance. Most importantly, the first resonance matches the size of real living cells.