Comorbidities in individuals with orofacial pain and their impact on biomarkers: Orofacial pain comorbidities and their impact on biomarkers

Abstract

This chapter covers the epidemiology of orofacial pain, the comorbidities implicated in chronic orofacial pain, as well as their relationship with specific biomarkers. More specifically, it reviews the prevalence of orofacial pain and of painful and non-painful comorbidities among individuals with orofacial pain. It also examines the implication of comorbidities in the onset and persistence of chronic orofacial pain. This chapter further discusses the role of comorbidities in the identification of biomarkers for chronic orofacial pain, which is largely unknown, and the clinical and research impacts of these findings.