Inclusion of noise in iterated firing time maps based on the phase response curve

Abstract

The infinitesimal phase response curve (PRC) of a neural oscillator to a weak input is a powerful predictor of network dynamics; however, many networks have strong coupling and require direct measurement of the PRC for strong inputs under the assumption of pulsatile coupling. We incorporate measured noise levels in firing time maps constructed from PRCs to predict phase-locked modes of activity, phase difference, and locking strength in 78 heterogeneous hybrid networks of 2 neurons constructed using the dynamic clamp. We show that noise may either destroy or stabilize a phase-locked mode of activity. © 2010 The American Physical Society.