Comorbid migraine is associated with a negative impact on quality of life in patients with major depression

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Abstract

This study investigated the impact of migraine on health-related quality of life (HRQoL) among patients with major depressive disorder (MDD). We prospectively enrolled 151 consecutive psychiatric out-patients meeting DSM-IV criteria for MDD. Migraine and other headache types were diagnosed based on the International Classification of Headache Disorders, 2nd edition (2004). The Short Form-36 (SF-36) was administered as a generic instrument of HRQoL. Among 151 patients with MDD, migraine (N = 73, 48.3%) was very common. Comorbidity of migraine predicted a significantly negative impact on all physical subscales and vitality but not on the other mental subscales of the SF-36 after controlling for depression, age and gender. The presence of migraine should be considered as an important physical symptom in clinic-based MDD samples. Simultaneous management of depression and severe headaches, especially migraine, might improve HRQoL in patients with MDD. © Blackwell Publishing Ltd.

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Hung, C. I., Liu, C. Y., Fuh, J. L., Juang, Y. Y., & Wang, S. J. (2006). Comorbid migraine is associated with a negative impact on quality of life in patients with major depression. Cephalalgia, 26(1), 26–32. https://doi.org/10.1111/j.1468-2982.2005.00985.x

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