Implication of sialidases in Salmonella infection: Genome release of sialidase knockout strains from salmonella enterica serovar Typhimurium LT2

Abstract

Sialidases, which are widely distributed in nature, cleave the α-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan. We report here the release of seven sialidase and one sialic acid transporter deletion in Salmonella enterica serovar Typhimurium strain LT2, which are important in cellular invasion during infection.