Mitochondrial dynamics related genes-mfn1, mfn2 and drp1 polymorphisms are associated with risk of lung cancer

Abstract

Purpose: This study aimed to evaluate the associations between mitochondrial dynamics related genes-MFN1, MFN2 and DRP1 polymorphisms and risk of lung cancer. Methods: Six polymorphisms of MFN1, MFN2 and DRP1 were genotyped in 600 cases and 600 controls using a MassARRAY platform. Results: The MFN1 rs13098637-C and DRP1 rs879255689-A alleles were associated with an increased risk of lung cancer (prs13098637=0.004, prs879255689=0.005), while MFN2 rs4240897-A and rs2236058-G were related to a decreased risk of disease (p<0.001). The rs13098637-TC/CC and rs879255689-GA/AA were determined as risk genotypes for lung cancer (prs13098637=0.014, prs879255689=0.013), whereas the rs4240897-GA/AA and rs2236058-GG were identified as protective genotypes against lung cancer risk (p<0.001). Genetic model analysis showed that rs13098637 was correlated with an elevated risk of lung cancer in dominant and log-additive models (pdominant=0.007, plog-additive=0.004). Moreover, rs879255689 was associated with an increased risk of disease in all three models (pdominant=0.014, precessive=0.028, plog-additive=0.005). In contrast, rs4240897 and rs2236058 were related to reduced risk of disease in all three models (rs4240897: pall<0.001; rs2236058: pdominant=0.008, precessive<0.001, plog-additive<0.001). In addition, these associations were related to the smoking status and pathological type of lung cancer patients. Conclusion: These results shed new light on the association between mitochondrial dynamics related genes and risk of lung cancer.