Inappropriate secretion of antidiuretic hormone treated with frusemide

Abstract

Seven out of 9 patients with chronic inappropriate secretion of antidiuretic hormone were successfully treated with 40 mg frusemide daily. One patient needed 80 mg, and the remaining patient achieved only a small increase in diuresis after 40 mg frusemide; this was probably related to his low creatinine clearance. In order to maintain a salt intake high enough to compensate for the loss of urine electrolytes, 3 to 6 g sodium chloride was added as tablets to the sodium-free diet in 6 patients. Hypokalemia occurred in 5 patients but was easily corrected with either supplements of potassium chloride or a potassium-sparing diuretic.