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Role of nonclassical renin-angiotensin system axis in renal fibrosis

Frontiers in Physiology (2015) 6(MAR)
DOI: 10.3389/fphys.2015.00117
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Abstract

The renin-angiotensin system (RAS) is a major regulator of renal fibrosis. Besides the classical renin/Angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/AT1 and AT2 axis, multiple new axes have been recently described. The new members have added new dimensions to RAS, including the ACE2/ANG (1-7)/Mas receptor axis, the prorenin/(pro)renin receptor (PRR)/intracelluar pathway axis, and the Angiotensin A (Ang A), alamandine-Mas-related G protein coupled receptor D (MrgD) axis. This review summarized recent studies regarding role of the non classical RAS axis in renal fibrosis, and its possible implications to the intervention of progression of chronic kidney disease.

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CITATION STYLE

APA

Lv, L. L., & Liu, B. C. (2015). Role of nonclassical renin-angiotensin system axis in renal fibrosis. Frontiers in Physiology, 6(MAR). https://doi.org/10.3389/fphys.2015.00117

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