Matrix-assisted laser desorption/ionization mass spectrometry imaging with laser-induced postionization (MALDI-2-MSI) has proven a powerful tool for the in situ analysis of N-linked glycosylation, or N-glycans, directly from clinical tissue samples. Here we describe a sample preparation protocol for the analysis of N-glycans from formalin-fixed, paraffin-embedded tissue sections.
CITATION STYLE
Soltwisch, J., & Heijs, B. (2023). Negative Ion-Mode N-Glycan Mass Spectrometry Imaging by MALDI-2-TOF-MS. In Methods in Molecular Biology (Vol. 2688, pp. 173–186). Humana Press Inc. https://doi.org/10.1007/978-1-0716-3319-9_15
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