In this issue of Molecular Cell, Fu et al. (2016) present a detailed structural analysis of death-inducing signaling complex (DISC) assembly and regulation through flexible caspase-8 interactions with cFLIPL, cFLIPS, and the viral inhibitor MC159, thereby identifying novel apoptosis control mechanisms.
Kinsella, S., & Prehn, J. H. M. (2016, October 20). In the Middle of a Chain Interaction. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2016.09.036