Netrin Synergizes Signaling and Adhesion through DCC

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Abstract

Netrin is a prototypical axon guidance cue. Structural studies have revealed how netrin interacts with the deleted in colorectal cancer (DCC) receptor, other receptors, and co-factors for signaling. Recently, genetic studies suggested that netrin is involved in neuronal haptotaxis, which requires a reversible adhesion process. Structural data indicate that netrin can also mediate trans-adhesion between apposing cells decorated with its receptors on the condition that the auxiliary guidance cue draxin is present. Here, we propose that netrin is involved in conditional adhesion, a reversible and localized process that can contribute to cell adhesion and migration. We suggest that netrin-mediated adhesion and signaling are linked, and that local environmental factors in the ventricular zone, the floor plate, or other tissues coordinate its function.

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Meijers, R., Smock, R. G., Zhang, Y., & Wang, J. H. (2020, January 1). Netrin Synergizes Signaling and Adhesion through DCC. Trends in Biochemical Sciences. Elsevier Ltd. https://doi.org/10.1016/j.tibs.2019.10.005

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