Synthesis, spectral characterization, thermal and biological studies of some novel schiff base metal(II) complexes

Abstract

Metal complexes of Co(II) and Ni(II) with Schiff base derived from 2-(2 fluorophenylmethylene) hydrazinecarboxamide (HL1) and 2-(2-fluorophenylmethylene) hydrazinecarbothioamide (HL2) were synthesized and characterized by elemental analysis, IR, UV-Visible and1 HNMR spectroscopy. On the basis of these studies, a hexa-coordinated octahedral geometry of Co(II) and Ni(II) complexes has been proposed. The thermal behavior (TGA) of Co(II) and Ni(II) complexes were studied to determine thermal stability. The ligand moieties and their complexes were collectively tested for their antimicrobial activity to assess their growth-inhibiting potential against bacteria and fungi. The ligands and their metal complexes were conjointly tested for antimycobacterial activity against Mycobacterium tuberculosis bacterial strain-H37RV-sensitive to isoniazid and rifampicin drugs. Thiosemicarbazone based [Co(L2)2 2H2O] was found to inhibit the expansion of Mycobacterium tuberculosisstrain (H37RV).