Adhesion Prevention: Past the Future

Abstract

Only recently has the prophylactic treatment of adhesions begun to gain acceptance by surgeons. Data continue to accumulate regarding the efficacy of film and fabric barriers (Interceed™, Seprafilm™, Preclude™), and are beginning to emerge regarding liquids such as Sepracoat™ and Intergel™ solutions. Newer film, gel, and liquid materials are in advanced stages of development and should be available for patients in the near future. These products represent advances in adhesion prevention. They have required innovation in biomaterials as well as creative clinical studies to demonstrate efficacy and to obtain regulatory approval. Despite these innovations, most products that become available in 2004 will have been developed by using materials designed for other purposes and optimizing them for adhesion prevention.