Background: MRI provides luminal, edema, & scar images which assist in the Electrophysiological (EP) treatment of ventricular and atrial arrhythmias]. Until a complete set of MR-compatible EP-devices is available, patients must be repeatedly moved between the MRI, where imaging and mapping occur, to the conventional EP suite, where puncture, navigation and Radio-Frequency Ablation occur. MRI-conditional voltage-based electroanatomic mapping (EAM) would permit efficient MRI-guided EP, with registration-free continuation outside MRI, utilizing X-ray, Intra-Cardiac-Echo (ICE) and EAM guidance. A 1.5T EnSite™ Velocity™ cardiac mapping system, a voltage-based EAM available from St. Jude Medical was previously validated [1,2]. Multiple-catheter EAM (localization and intra-cardiac electrocardiogram (EGM) measurement) inside a 3T MRI requires modifications. Methods: An EnSite™ Velocity™ system was connected to an electronic switching circuit that prevents induced MRI gradient-ramp noise from corrupting ECG fidelity. Electrode tracking is preserved with software blanking. The system also included RF-filtered electrical lines, modified EnSite™ NavX™ surface electrodes, and gold electrode EP catheters [2]. Trans-septal punctures were made in 2 intubated swine under X-ray & ICE guidance. Millar catheters were placed in the aorta to monitor Invasive Blood Pressure (IBP). The swine were moved to a Siemens 3.0T MRI suite equipped with an EnSite™ Velocity™ system. A 12-lead MRI-compatible ECG [3] was also used. Three EP catheters, with 4 voltage-tracked electrodes each, were navigated simultaneously inside the MRI to acquire EAM of the heart's left & right sides, with a coronary sinus catheter for physiological reference. Imaging & EAM were performed simultaneously (Figure 1). To measure the EnSite™ Velocity™ system's catheter tracking accuracy during MR imaging, catheters were navigated to specific anatomic regions, and the change in location was observed during imaging over 10 sec increments. Results: EAM & catheter navigation in swine were performed both inside & outside the MRI at >20 frames-per-second without re-registration (Figure 1). Imaging was conducted simultaneously with tracking, with catheter position stable (+1 mm) during imaging in TR>32 ms sequences. Median catheter electrode locations changed by < 0.5 mm between inside and outside MRI. An added ventricular signal was observed on intra-MRI atrial EGMs (Figure 1B), due to Magnetohydrodynamics. IBP detected a cardiac event (Figure 2), followed by successful CPR & defibrillation in the MRI suite. MRI Image quality reduction was < 5%, although catheter artifacts during SSFP were excessive (Figure 3), requiring catheter redesign. Conclusions: 3T MRI-conditional voltage tracking allows simultaneous catheter tracking & MR imaging, permitting registration-free EAM inside & outside MRI during EP procedures. (Figure Presented).
CITATION STYLE
Zhang, S. H., Tse, Z. T., Dumoulin, C. L., Bryd, I., Schweitzer, J., Watkins, R. G., … Schmidt, E. J. (2014). MRI-compatible voltage-based electroanatomic mapping system for 3T MR-guided cardiac electrophysiology: swine validations. Journal of Cardiovascular Magnetic Resonance, 16, P140. https://doi.org/10.1186/1532-429x-16-s1-p140
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