Background: Extracellular acidification promotes structural rearrangements in the ectodomain of ASIC1a that result in activation and desensitization. Results: Glu-79 and Glu-416 cooperatively facilitate proton gating. The lower palm domain contracts upon extracellular acidification. Conclusion: The lower palm domain mediates conformational changes that drive pore opening and closing events. Significance: This study provides insight into the molecular mechanism of gating of epithelial sodium/degenerin channels. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
CITATION STYLE
Vecchia, M. C. D., Rued, A. C., & Carattino, M. D. (2013). Gating transitions in the palm domain of ASIC1a. Journal of Biological Chemistry, 288(8), 5487–5495. https://doi.org/10.1074/jbc.M112.441964
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